Saturday, February 22, 2014

For melanoma...eat that curry...again!!! We just don't know why!

I've posted articles here before, regaling the benefit of curcumin (Turmeric- the yellow part of mustard and curry).  Curcumin has long been proven to eradicate melanoma...at least in a petri dish. And while that's nice and all...how am I supposed to get my melanoma cells in that dish???!!!  Well, this study took that up a notch!

Curcumin Intake Affects md RNA Dignature in Murein Melanoma with mmu-miR-205-5p Most Significantly Altered.  Dahmke, et al.  PLoS One. Dec 2013.

"Melanoma is the most aggressive form of skin cancer with an estimated 48,000 deaths per year worldwide. The polyphenol curcumin derived from the plant Curcuma longa is well known for its anti-inflammatory and anti-cancerogenic properties.  Accordingly, dietary intake of the compound may be suitable for melanoma prevention.  However, how this compound affects basic cellular mechanisms in developing melanoma still remains elusive. Therefore, the aim of this study was to investigate for the first time the impact of oral curcumin administration on the miRNA signature of engrafting melanoma."  So...ratties (real rats...this time) were given melanoma tumors on their sides.  But, they were fed their regular chow OR a curcumin diet two weeks prior to the tumor cell injection and until the experiment was stopped. "Curcumin significantly reduced the growth of the flank tumors.  Furthermore, the miRNA expression signature in tumors was substantially altered by curcumin intake with mmu-miR-205-5p over 100 times higher expressed when compared to controls."

Well!  You go my little real live curcumin eating ratties with your altered mmu-miR-205-5p!!!!  I'm gonna see if I can alter mine, too!!! Curry with a side of mustard, anyone? - c

2 comments:

  1. I'm glad to see the study done in this manner! That is exactly what I keep wondering when the studies talk about strawberries and etc. applied to cancer cells in a dish! It's good news that you can EAT your curry! :)

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